Mexitil, Namuscla(mexiletine hydrochloride)
Mexiletine, Namuscla (mexiletine hydrochloride) is a small molecule pharmaceutical. Mexiletine hydrochloride was first approved as Mexitil on 1985-12-30. It is used to treat cardiac arrhythmias, diabetic neuropathies, ventricular fibrillation, and ventricular premature complexes in the USA. It has been approved in Europe to treat myotonic disorders.
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Mexiletine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MEXITIL | Boehringer Ingelheim | N-018873 DISCN | 1985-12-30 | 3 products, RLD |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| mexiletine hcl | 2008-04-29 | |
| mexiletine hydrochloride | ANDA | 2024-08-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myotonic disorders | Orphanet_606 | D020967 | G71.1 |
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30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventricular tachycardia | D017180 | — | I47.2 | — | — | 1 | 2 | 1 | 4 |
| Tachycardia | D013610 | HP_0001649 | R00.0 | — | — | 1 | 2 | 1 | 4 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | 2 | 1 | — | 3 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 2 | — | 1 | — | 3 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 2 | — | 1 | — | 3 |
| Sclerosis | D012598 | — | — | — | 2 | — | 1 | — | 3 |
| Muscle cramp | D009120 | HP_0003394 | — | — | 1 | — | 1 | — | 2 |
| Spasm | D013035 | — | M62.83 | — | 1 | — | 1 | — | 2 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myotonic dystrophy | D009223 | — | G71.11 | — | 2 | 4 | — | 1 | 7 |
| Myotonia | D009222 | HP_0002486 | — | — | 2 | 2 | — | 1 | 5 |
| Myotonic disorders | D020967 | Orphanet_606 | G71.1 | — | — | 2 | — | 2 | 4 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 2 | — | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | — | 2 |
| Ventricular fibrillation | D014693 | HP_0001663 | I49.01 | — | — | 2 | — | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | — | 1 |
| Myotonia congenita | D009224 | — | G71.12 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nerve compression syndromes | D009408 | — | — | — | 1 | — | — | — | 1 |
| Tooth diseases | D014076 | — | — | — | 1 | — | — | — | 1 |
| Charcot-marie-tooth disease | D002607 | EFO_0004148 | G60.0 | — | 1 | — | — | — | 1 |
| Hereditary sensory and motor neuropathy | D015417 | — | G60.0 | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | 1 | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Pharmacological phenomena | D000069437 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mexiletine hydrochloride |
| INN | mexiletine |
| Description | Mexiletine is an aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol. It has a role as an anti-arrhythmia drug. It is an aromatic ether and a primary amino compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cccc(C)c1OCC(C)N.Cl |
Identifiers
| PDB | — |
| CAS-ID | 5370-01-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200606 |
| ChEBI ID | 6917 |
| PubChem CID | 4178 |
| DrugBank | DB00379 |
| UNII ID | 1U511HHV4Z (ChemIDplus, GSRS) |
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965 adverse events reported
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